Translational Engineering Approaches for Pulmonary Health Sciences

Pulmonary Health Sciences

In vitro testing of aerosol delivery has been found to be effective in predicting behavior of particles in an in vivo setting, making it possible to evaluate and quantify characteristics of certain drug delivery methods without the uncertainty of in vivo testing. The benefits of realistic in vitro testing allow direct comparison and quantification of factors that ultimately define how aerosol will be deposited in specific regions of the airways. It also allows for the evaluation of a wide range of innovative inhalation delivery methods, which could be utilized for different drugs and age groups. By having several in vitro models, it is also possible to determine the effects of intersubject variability and develop methods to include the anatomical differences to optimize the delivery techniques for different individuals

Projects will include:

  • Design and development of anatomical 3D printed airway models with close relevance to human airway functions.
  • Design and development of age-specific pulmonary drug delivery devices.
  • Design and development of targeted pulmonary drug delivery techniques.
  • Design and development of devices and methods to mitigate adverse effects of toxic aerosols, pollutants and allergens.

Interested? Contact Prof. Laleh Golshahi (lgolshahi@vcu.edu)